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KMID : 0380620190510040398
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Korean Journal of Food Science and Technology
2019 Volume.51 No. 4 p.398 ~ p.403
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Enhancement of immune activities of Dioscorea japonica Thunberg in in vivo and ex vivo models
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Lim Seok-Won
Kim Na-Hyung
Cho Hi-Jae
Jeong Hyun-Ja
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Abstract
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Dioscorea japonica Thunberg (DJ) has been widely used as a healthy food in Korea for the enhancement of physical stamina. Hence, the present study evaluated the immune-enhancing effect of DJ in forced swim test of mouse model. The immobility time of the group treated with DJ for 7 days was significantly reduced in comparison with that of the control group. After a forced swimming test, the changes in blood biochemical parameters and splenic T lymphocyte populations induced by the administration of DJ were assessed. Serum levels of lactic dehydrogenase, creatine phosphokinase, and aspartate aminotransferase were significantly decreased in DJ-administered group compared to the control group. However, administration of DJ did not affect the splenic T lymphocyte populations. Moreover, DJ significantly increased the production of interferon-g and interleukin-2 compared to the media control in splenocytes. Collectively, it may be concluded that DJ is useful for enhancement of physical and immune function.
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KEYWORD
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Dioscorea japonica Thunberg, forced swimming test, interferon-g, interleukin-2, immune-enhancement
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